Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion
2022 · Circulation Research
저자
Dongwon Choi, Eunkyung Park, Roy P. Yu, Michael N. Cooper, Il‐Taeg Cho, Joshua Choi, James Yu, Luping Zhao, Ji-Eun Irene Yum, Jin Suh Yu, Brandon Nakashima, Sunju Lee, Young Jin Seong, Jiao Wan, Chester J. Koh, Peter Bałuk, Donald M. McDonald, Sindhu Saraswathy, Jong Yeon Lee, 전누리 (Noo Li Jeon), Zhenqian Zhang, Alex S. Huang, Bin Zhou, Alex K. Wong, Young‐Kwon Hong
연구주제
NTIS 과학기술표준분류
에너지/자원만에너지·환경·원자력 확장
지원 과제·AI 키워드로 잡을 근거가 없어 분류하지 않았다.
AI 연구 키워드·방법
lymphatic sprouting lymphedema mechanotransduction piezo1 mechanosensitive channel
transgenic mouse model
키워드 (OpenAlex)
Piezo1 mechanotransduction lymphatic endothelial cells Orai1 fluid flow Notch signaling KLF2 DTX3L
초록
BACKGROUND: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1) cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI calcium release-activated calcium modulator 1)-mediated mechanotransduction pathway that triggers lymphatic sprouting through Notch downregulation in response to fluid flow. However, the identity of its upstream mechanosensor remains unknown. This study aimed to identify and characterize the molecular sensor that translates the flow-mediated external signal to the Orai1-regulated lymphatic expansion. METHODS: Various mutant mouse models, cellular, biochemical, and molecular biology tools, and a mouse tail lymphedema model were employed to elucidate the role of Piezo1 in flow-induced lymphatic growth and regeneration. RESULTS: Piezo1 was found to be abundantly expressed in lymphatic endothelial cells. Piezo1 knockdown in cul…
이 논문을 지원한 국가R&D 과제 (NTIS 성과)
| 연도 | 과제 | 부처 | 사업 | 수행기관 | NTIS 분류(1순위) |
|---|---|---|---|---|---|
| 2022 | 창의융합형 세계선도 기계공학 미래인재 교육연구단 | 교육부 | 4단계두뇌한국21사업(R&D) | 서울대학 | – |
인접 그래프
노드 hover = 이웃 강조 · 1회 클릭 = 고정 · 고정된 노드 다시 클릭 = 페이지 이동