MOF‐Based Single‐Atom and Metal Cluster Catalysts by Room‐Temperature Synthesis for Tumor Therapy

Abstract Metal–organic frameworks (MOFs) are widely used as substrates for creating single‐atom catalysts due to their abundance of ligands, facilitating enzyme‐like activity for biomedical applications. However, the high‐temperature calcination process for single‐atom catalysts limits economical, efficient, and large‐scale synthesis. Here, a simple room‐temperature synthesis of MOF‐based single‐atom and metal cluster catalysts is presented for tumor therapy. Fe/MOF is obtained through a coordination reaction at room temperature, while Au/MOF is synthesized from Au 3+ /MOF by introducing a reducing agent. Au/MOF effectively generates hydrogen peroxide (H 2 O 2 ) from glucose, outperforming Au 3+ /MOF, and Fe/MOF subsequently produced hydroxyl radicals (•OH) by decomposing the generated H 2 O 2 via accelerated peroxidase‐like activity in an acidic environment. In vitro and in vivo studies…