Simultaneous Measurement of Circular Dichroism and Circular Differential Scattering

Chiroptical spectroscopy provides a non-invasive, label-free approach for resolving microscopic structural details via interactions with circularly polarized light. Despite the widespread application and complementary information provided for chiroptical materials characterization, the simultaneous acquisition of circular dichroism (CD) and circular differential scattering (CDS) spectra has remained challenging. In this work, we develop a dual-channel spectrometer that enables the acquisition of CD and CDS spectra from the same solution. To address the challenge of CDS baseline correction, we introduce a scattering spectral matching method. The performance of the instrument is validated using two representative model systems: a mixture of ammonium d-10 camphor sulfonate and polystyrene nanoparticles (PSNPs), and plasmonic gold helicoid nanoparticles, which exhibit both chiral absorption …