Plasmonic Nanoparticle-Metal–Organic Framework Hybrid Nanostructures for Biomedical Applications: From Design to Function

Plasmonic nanoparticle-metal-organic framework (plasmonic NP-MOF) hybrid nanostructures have emerged as distinctive platforms that synergistically combine the physical, chemical, and biological properties and functions of plasmonic nanoparticles and MOFs, enabling biomedical capabilities inaccessible to either component alone. This Perspective focuses on a central design-to-function relationship: the structural paradigm between the plasmonic nanoparticle and the MOF governs how the properties of the two components complement one another and interact synergistically. We consider four principal configurations: plasmonic NPs embedded within MOF pores, plasmonic NPs decorate the MOF exterior, and a plasmonic NP serves as the core of a plasmonic@MOF core-shell structure or forms the shell of a MOF@plasmonic NP core-shell structure. Each configuration offers distinct functional advantages suit…